Intracerebral steal phenomenon in symptomatic carotid artery disease

Abstract

Background and purpose: Intracerebral steal is a paradoxical vasodilatory response that reduces cerebral blood flow (CBF) in hemodynamically compromised brain tissue when blood is rerouted to more healthy areas. The aim of our study was to investigate the presence and extent of steal in patients with steno-occlusive internal carotid artery (ICA) disease, and to assess its relation with collateral blood flow through the circle of Willis (CoW). Materials and methods: Thirty-eight patients with symptomatic steno-occlusive ICA disease underwent MRI examination with arterial spin labeling (ASL) perfusion imaging before and after a vasodilatory challenge. Intracerebral steal was defined as a decline in CBF after acetazolamide. Collateral flow via the CoW was assessed with time-of-flight and flow direction MR angiography (MRA) through the CoW was assessed with 2D phase-contrast MRA's. Results: Eight of 38 patients (21%) had steal in the hemisphere ipsilateral to the symptomatic ICA (mean tissue volume with steal, 6.9 ± 4.1 mL; mean CVR, −11 ± 30%). Cerebrovascular reactivity (CVR) was lower in the middle cerebral artery flow territory of the affected hemisphere in patients with steal compared those without (P = 0.002). Collateral blood flow was impaired in 4 of the 8 patients with steal. These patients had a larger area of steal (P = 0.002). Conclusions: Intracerebral steal occurs in patients with obstructive ICA disease and can be assesses at brain tissue level with ASL perfusion MRI. Its presence is related to more severely declined CVR in the surrounding brain tissue area and the volume is associated with impaired primary collateral blood flow through the CoW.