Invasive pneumococcal disease leads to activation and hyperreactivity of platelets
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Publication date
2016-08-01
Authors
Tunjungputri, Rahajeng N.
De Jonge, Marien I.
De Greeff, Astrid
Van Selm, Saskia
Buys, Herma
Harders-Westerveen, Jose F.
Stockhofe-Zurwieden, Norbert
Urbanus, Rolf
de Groot, Philip G.
Smith, Hilde E.
Editors
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Supervisors
Document Type
Letter
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taverne
Abstract
Using a novel porcine model of intravenous Streptococcus pneumoniae infection, we showed that invasive pneumococcal infections induce marked platelet activation and hyperreactivity. This may contribute to the vascular complications seen in pneumococcal infection.
Keywords
Infection, Myocardial infarction, Platelet activation, Platelets, Pneumonia, Streptococcus pneumoniae, Taverne, Hematology, Letter
Citation
Tunjungputri, R N, De Jonge, M I, De Greeff, A, Van Selm, S, Buys, H, Harders-Westerveen, J F, Stockhofe-Zurwieden, N, Urbanus, R T, de Groot, P G, Smith, H E, Van Der Ven, A J & De Mast, Q 2016, 'Invasive pneumococcal disease leads to activation and hyperreactivity of platelets', Thrombosis Research, vol. 144, pp. 123-126. https://doi.org/10.1016/j.thromres.2016.06.016