Inhibition of gastric secretion by bacterial lipopolysaccharide in the rat

Abstract

Bacterial lipopolysaccharide (LPS) provoked an inhibition of gastric secretion in the rat. Reserpine and the catecholamine-synthesis inhibitors α-methyldopa and diethyl dithiocarbamate blocked this action of LPS, although adrenergic blocking agents or adrenalectomy were without effect. Direct stimulation of gastric secretion by carbachol also opposed the LPS effect, whereas central parasympathetic stimulation by 2-deoxy-D-glucose did not.