Augmentation of the pressor response to octapressin by autonomic blocking agents in the pithed rat

Abstract

The effect of octapressin on blood pressure was studied in anesthetized pithed male rats, pretreated with autonomic blocking agents. Phenoxybenzamine and chlorpromazine induced an augmentation of the blood pressure response to octapressin, whereas atropine, propranolol and hexamethonium had no effect on the response to octapresin in the pithed rat.

It is concluded that phenoxybenzamine and chlorpromazine augment the blood pressure response to octapressin in the pithed rat by a direct effect on the peripheral vascular effector cells.