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C-N coupling of nitrogen nucleophiles with aryl and heteroaryl bromides using aminoarenethiolato-copper(I) (pre-)catalyst

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Publication date

2010

Authors

Sperotto, E.ISNI 000000038992675X
van Klink, G.P.M.ISNI 000000039075393X
de Vries, J.G.
van Koten, G.ISNI 0000000389131797

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DOI

https://doi.org/10.1016/j.tet.2010.03.040

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Article

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Abstract

The activity of a library of 2-aminoarenethiolato–copper(I) (CuSAr) (pre-)catalyst was explored in the arylation reaction of amines and N-containing heterocycles with aryl and heteroaryl bromides, respectively. These CuSAr pre-catalysts are thermally stable, are soluble in common organic solvents and show good catalytic activities in these N-arylation reactions with catalyst loadings amounting to 2.5 mol %. The targeted C–N coupling products were obtained in moderate to good yields (40–97%) for a variety of substrates.

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Sperotto, E, van Klink, G P M, de Vries, J G & van Koten, G 2010, 'C-N coupling of nitrogen nucleophiles with aryl and heteroaryl bromides using aminoarenethiolato-copper(I) (pre-)catalyst', Tetrahedron, vol. 66, no. 19, pp. 3478-3484. https://doi.org/10.1016/j.tet.2010.03.040

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https://dspace.library.uu.nl/handle/1874/200573