Back Cover: DNP-Supported Solid-State NMR Spectroscopy of Proteins Inside Mammalian Cells (Angew. Chem. Int. Ed. 37/2019)
Publication date
2019-09-09
Authors
Narasimhan, S.
Scherpe, Stephan
Lucini Paioni, Alessandra
van der Zwan, Johan
Folkers, Gert E
Ovaa, Huib
Baldus, Marc
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Supervisors
Document Type
Article
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taverne
Abstract
Dynamic nuclear polarization (DNP) enhanced solid‐state NMR (ssNMR) spectroscopy enables atomic‐level structural studies of isotope labeled proteins at physiologically relevant concentrations in mammalian cells, irrespective of the tumbling rate of the protein of interest, as reported by H. Ovaa, M. Baldus, and co‐workers in their Communication on page 12969 ff. In the absence of DNP, NMR sensitivity levels are insufficient to conduct such studies.
Keywords
dynamic nuclear polarization, in-cell NMR, protein-protein interactions, solid-state NMR, ubiquitination, Taverne
Citation
Narasimhan, S, Scherpe, S, Lucini Paioni, A, van der Zwan, J, Folkers, G E, Ovaa, H & Baldus, M 2019, 'Back Cover: DNP-Supported Solid-State NMR Spectroscopy of Proteins Inside Mammalian Cells (Angew. Chem. Int. Ed. 37/2019)', Angewandte Chemie-International Edition, vol. 58, no. 37, pp. 13162. https://doi.org/10.1002/anie.201908849