Neisseria meningitidis Serogroup Z Meningitis in a Child with Complement C8 Deficiency and Potential Cross Protection of the MenB-4C Vaccine
Publication date
2021-11
Authors
Van Den Broek, Bryan
Coolen, Jordy P.M.
De Jonge, Marien I.
de Groot, Ronald
Henriet, Stefanie S.V.
Langereis, Jeroen D.
van der Flier, M.
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Advisors
Supervisors
Document Type
Article
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taverne
Abstract
Complement deficient patients are susceptible to rare meningococcal serogroups. A 6-year-old girl presented with serogroup Z meningitis. This led to identification of a C8 deficiency. The MenB-4C vaccine induced cross-reactive antibodies to serogroup Z and increased in vitro opsonophagocytic killing and may thus protect complement deficient patients.
Keywords
complement deficiency, immune compromised, MenB-4C, Neisseria meningitidis, vaccine, Taverne, Pediatrics, Perinatology, and Child Health, Microbiology (medical), Infectious Diseases
Citation
Van Den Broek, B, Coolen, J P M, De Jonge, M I, De Groot, R, Henriet, S S V, Langereis, J D & Van Der Flier, M 2021, 'Neisseria meningitidis Serogroup Z Meningitis in a Child with Complement C8 Deficiency and Potential Cross Protection of the MenB-4C Vaccine', Pediatric Infectious Disease Journal, vol. 40, no. 11, pp. 1019-1022. https://doi.org/10.1097/INF.0000000000003259