Recent advances in viral evasion of the MHC Class I processing pathway
Publication date
2016-06
Authors
Schuren, Anouk Bc
Costa, A.I.
Wiertz, EJHJ
Editors
Advisors
Supervisors
Document Type
Article
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taverne
Abstract
T-cell mediated adaptive immunity against viruses relies on recognition of virus-derived peptides by CD4(+) and CD8(+) T cells. Detection of pathogen-derived peptide-MHC-I complexes triggers CD8(+) T cells to eliminate the infected cells. Viruses have evolved several mechanisms to avoid recognition, many of which target the MHC-I antigen-processing pathway. While many immune evasion strategies have been described in the context of herpesvirus infections, it is becoming clear that this 'disguise' ability is more widespread. Here, we address recent findings in viral evasion of the MHC-I antigen presentation pathway and the impact on CD8(+) T cell responses.
Keywords
Animals, Antigen Presentation, Antigens, Viral, CD8-Positive T-Lymphocytes, Cytotoxicity, Immunologic, Gene Expression Regulation, Histocompatibility Antigens Class I, Humans, Immune Evasion, Killer Cells, Natural, Virus Diseases, Viruses, Journal Article, Review, Taverne
Citation
Schuren, A B, Correia de Almeida Costa, AI & Wiertz, E J 2016, 'Recent advances in viral evasion of the MHC Class I processing pathway', Current Opinion in Immunology, vol. 40, pp. 43-50. https://doi.org/10.1016/j.coi.2016.02.007