The TCR assigns naive T cells to a preferred lymph node
Publication date
2024-07-26
Authors
de Greef, Peter Cornelis
Njeru, Sospeter Ngoci
Benz, Claudia
Fillatreau, Simon
Malissen, Bernard
Agenès, Fabien
Boer, Rob J. De
Kirberg, Jörg
Editors
Advisors
Supervisors
Document Type
Article
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License
cc_by_nc
Abstract
Naive T cells recirculate between the spleen and lymph nodes where they mount immune responses when meeting dendritic cells presenting foreign antigen. As this may happen anywhere, naive T cells ought to visit all lymph nodes. Here, deep sequencing almost-complete TCR repertoires led to a comparison of different lymph nodes within and between individual mice. We find strong evidence for a deterministic CD4/CD8 lineage choice and a consistent spatial structure. Specifically, some T cells show a preference for one or multiple lymph nodes, suggesting that their TCR interacts with locally presented (self-)peptides. These findings are mirrored in TCR-transgenic mice showing localized CD69 expression, retention, and cell division. Thus, naive T cells intermittently sense antigenically dissimilar niches, which is expected to affect their homeostatic competition.
Keywords
Animals, Antigens, CD/metabolism, Antigens, Differentiation, T-Lymphocyte/metabolism, CD4-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/immunology, Lectins, C-Type/metabolism, Lymph Nodes/immunology, Mice, Mice, Transgenic, Receptors, Antigen, T-Cell/metabolism, T-Lymphocytes/immunology
Citation
de Greef, P C, Njeru, S N, Benz, C, Fillatreau, S, Malissen, B, Agenès, F, de Boer, R J & Kirberg, J 2024, 'The TCR assigns naive T cells to a preferred lymph node', Science advances, vol. 10, no. 30, eadl0796. https://doi.org/10.1126/sciadv.adl0796