Versatile selective α-carboxylic acid esterification of N-protected amino acids and peptides by alcalase
Publication date
2009-01-28
Authors
Nuijens, T.
Cusan, Claudia
Kruijtzer, John
Rijkers, D.T.S.
Liskamp, Rob M.J.
Quaedflieg, Peter J. L. M.
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Document Type
Article
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Abstract
Under continuous removal of water, the industrial protease Alcalase allows selective synthesis of α-carboxylic acid methyl, ethyl, benzyl, allyl, 2-(trimethylsilyl)ethyl, and tert-butyl esters of amino acids and peptides under mild conditions in very high yields. The purified yields range from 72% to 92%. © Georg Thieme Verlag Stuttgart.
Keywords
Amino acids, Enzymes, Esterification, Esters, Protecting groups, amino acid, carboxylic acid derivative, ester, ester derivative, peptide, subtilisin, article, esterification, synthesis
Citation
Nuijens, T, Cusan, C, Kruijtzer, J A W, Rijkers, D T S, Liskamp, R M J & Quaedflieg, P J L M 2009, 'Versatile selective α-carboxylic acid esterification of N-protected amino acids and peptides by alcalase', Synthesis, vol. 2009, no. 5, pp. 809-814. https://doi.org/10.1055/s-0028-1083362