Receptor-binding specificity and antigenic properties of a genotype D1.1 A(H5N1) influenza virus isolated from a human
Publication date
2026
Authors
Kandeil, Ahmed
Chopra, Pradeep
Ray, Sean D
Ghotekar, Balasaheb K
Ranadheera, Charlene
Jeevan, Trushar
Fabrizio, Thomas
Rubrum, Adam
Boons, Geert-Jan
Tompkins, Stephen Mark
Editors
Advisors
Supervisors
Document Type
Article
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cc_by_nc
Abstract
Clade 2.3.4.4b A(H5N1) influenza viruses continue to expand their host range and pose increasing public health concerns. A case of severe human infection with genotype D1.1 A(H5N1) with HÀ substitutions was diagnosed in British Columbia. It is important to monitor receptor-binding specificity and antigenicity of emerging variants of circulating influenza A(H5N1) viruses. To evaluate potential human adaptation of this virus, we enriched HA-variant subpopulations and assessed sialic acid receptor usage via glycan microarray, solid-phase assays, and biolayer interferometry. All variants bound exclusively to avian-type sialic acid receptors. The antigenicity of the tested A(H5N1) variants was covered by candidate vaccine viruses.
Keywords
H5N1, Hemagglutinin, Influenza, emerging variants, receptor-binding specificity, SDG 3 - Good Health and Well-being
Citation
Kandeil, A, Chopra, P, Ray, S D, Ghotekar, B K, Ranadheera, C, Jeevan, T, Fabrizio, T, Rubrum, A, Boons, G-J, Tompkins, S M, Bastien, N & Webby, R J 2026, 'Receptor-binding specificity and antigenic properties of a genotype D1.1 A(H5N1) influenza virus isolated from a human', Emerging microbes & infections, vol. 15, no. 1, 2645856. https://doi.org/10.1080/22221751.2026.2645856