Molecular cloning of cat interleukin 12
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Publication date
1997
Authors
Horzinek, M.C.
Schijns, Virgil E.C.J.
Wierda, C.M.
Vahlenkamp, T.W.
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Document Type
Article
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Abstract
The recently discovered interleukin-12 (IL-12) is a heterodimeric
70000 Mr cytokine composed of a disulphide-bonded 35000 Mr
(p35) subunit and a 40000 Mr (p40) subunit. Produced mainly by
activated monocytes/macrophages and B cells, it enhances NK/LAK
cell cytolytic activity and stimulates cytotoxic T-cell responses and
IFN-γ production. It is therefore a key
regulatory molecule in T-helper-cell type-1 (Th-1)-driven immune
responses that are considered necessary for the elimination of intracellular
pathogens.