[18F]FDG-avid nodal gliomatosis associated with ovarian immature teratoma – The importance of histological confirmation
Publication date
2026-06
Authors
Queiró, Luisa
Hulsker, Caroline C C
Looijenga, Leendert H J
De Krijger, Ronald R.
Scheijde-Vermeulen, Marijn
Kusters, Pascal J.H.
Littooij, Annemieke Simone
van Leeuwen, J H S
Braat, A. J.A.T.
Mavinkurve-Groothuis, Annelies M.C.
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Document Type
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Abstract
Gliomatosis is a rare condition mainly associated with ovarian teratomas. It is characterized by the presence of mature glial tissue in extraovarian sites and most frequently found in the peritoneum (gliomatosis peritonei). Gliomatosis in the lymph nodes (nodal gliomatosis) has rarely been reported. We discuss a case of a 4-year-old girl with immature ovarian teratoma with concomitant gliomatosis peritonei and nodal gliomatosis, detected with magnetic resonance imaging (MRI) and Fluorine-18 fluorodeoxyglucose positron-emission tomography/computed tomography ([18F]FDG PET/CT) as [18F]FDG-avid lesions. Histologic examination showed mature well differentiated glial tissue. We aim to highlight the importance of histopathologic assessment of [18F]FDG positive lesions that may initially appear metastatic.
Keywords
Germ cell tumour, Gliomatosis peritonei, Immature teratoma, Nodal gliomatosis, [18 F]FDG-avidity, Dentistry (miscellaneous), Biochemistry, Genetics and Molecular Biology (miscellaneous), Hematology, Oncology, Radiology Nuclear Medicine and imaging
Citation
Queiró, L, Hulsker, C C C, Looijenga, L H J, de Krijger, R R, Scheijde-Vermeulen, M A, Kusters, P J H, Littooij, A S, van Leeuwen, J, Braat, A J A T & Mavinkurve-Groothuis, A M C 2026, '[ 18 F]FDG-avid nodal gliomatosis associated with ovarian immature teratoma – The importance of histological confirmation', EJC Paediatric Oncology, vol. 7, 100493. https://doi.org/10.1016/j.ejcped.2026.100493