Linear synthesis and immunological properties of a fully synthetic vaccine candidate containing a sialylated MUC1 glycopeptide
Files
Publication date
2015-05-28
Authors
Thompson, Pamela
Lakshminarayanan, Vani
Supekar, Nitin T.
Bradley, Judy M.
Cohen, Peter A.
Wolfert, Margreet A.
Gendler, Sandra J.
Boons, Geert-Jan
Editors
Advisors
Supervisors
Document Type
Article
Metadata
Show full item recordCollections
License
taverne
Abstract
A strategy for the linear synthesis of a sialylated glycolipopeptide cancer vaccine candidate has been developed using a strategically designed sialyl-Tn building block and microwave-assisted solid-phase peptide synthesis. The glycolipopeptide elicited potent humoral and cellular immune responses. T-cells primed by such a vaccine candidate could be restimulated by tumor-associated MUC1.
Keywords
Taverne, General Chemistry, Catalysis, Ceramics and Composites, Electronic, Optical and Magnetic Materials, Surfaces, Coatings and Films, Materials Chemistry, Metals and Alloys, SDG 3 - Good Health and Well-being
Citation
Thompson, P, Lakshminarayanan, V, Supekar, N T, Bradley, J M, Cohen, P A, Wolfert, M A, Gendler, S J & Boons, G J 2015, 'Linear synthesis and immunological properties of a fully synthetic vaccine candidate containing a sialylated MUC1 glycopeptide', Chemical Communications, vol. 51, no. 50, pp. 10214-10217. https://doi.org/10.1039/c5cc02199e