Hold the fold: how delayed folding aids protein secretion
Publication date
2022-12-01
Authors
McCaul, Nicholas
Braakman, I.
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Advisors
Supervisors
Document Type
Article
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License
taverne
Abstract
In bacteria, N-terminal signal peptides mark proteins for transport across the plasma membrane. A recent study by Smets et al (2022) followed the folding of a pair of structural twins to shed light on how evolution has optimised the secretory process.
Keywords
Protein Transport, Protein Sorting Signals, Proteins, Cell Membrane, Protein Folding, Taverne, SDG 3 - Good Health and Well-being
Citation
McCaul, N & Braakman, I 2022, 'Hold the fold : how delayed folding aids protein secretion', EMBO Journal, vol. 41, no. 23, e112787. https://doi.org/10.15252/embj.2022112787