Heritability of menopausal age in mothers and daughters
Publication date
2004
Authors
van Asselt, Kristel M.
Kok, Helen S.
Pearson, Peter L.
Dubas, Judith S.
Peeters, Petra H.
te Velde, Egbert R.
van Noord, Paulus A. H.
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Abstract
Objective: To determine the heritability of age at natural menopause from mother-daughter pairs. Design: Two-generation families were selected to study heritability of menopausal age. Setting: Subjects were drawn from a population-based study. Patient(s): One hundred sixty-four mother-daughter pairs with a natural menopausal age. Intervention(s): None. Main Outcome Measure(s): The heritability of age at natural menopause estimated by a random-effects model. Result(s): A heritability of 44% (95% confidence interval, 36%, 50%) was estimated. Conclusion(s): This study confirms that heritable components largely determine the natural age at menopause. Reasons for the differences between heritability estimates based on sibling pairs and parent-child comparisons are discussed. (C) 2004 by American Society for Reproductive Medicine
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van Asselt, K M, Kok, H S, Pearson, P L, Dubas, J S, Peeters, P H M, te Velde, E R & van Noord, P A H 2004, 'Heritability of menopausal age in mothers and daughters', Fertility and Sterility, vol. 82, no. 5, pp. 1348-1351. https://doi.org/10.1016/j.fertnstert.2004.04.047