NFκB and MHC-1 Interplay in Neuroblastoma and Immunotherapy
Publication date
2018-11-01
Authors
Spel, Lotte
Schiepers, Ariën
Boes, Marianne
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Supervisors
Document Type
Article
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taverne
Abstract
Pediatric neuroblastoma tumors are notorious nonimmunogenic cancers. In contrast to adult tumor types, neuroblastoma cells express low MHC-1, a derivative of its embryonic cell origin expressing little MHC-1. We here address the role of the nuclear factor kappa B (NFκB) pathway in controlling MHC-1 expression in embryonic neural crest cells, during differentiation of healthy cells, and in neuroblastoma tumors. Implications for immunotherapy are discussed.
Keywords
immunotherapy, MHC-1, neural crest, neuroblastoma, nuclear factor kappa B, Taverne, Oncology, Cancer Research
Citation
Spel, L, Schiepers, A & Boes, M 2018, 'NFκB and MHC-1 Interplay in Neuroblastoma and Immunotherapy', Trends in Cancer, vol. 4, no. 11, pp. 715-717. https://doi.org/10.1016/j.trecan.2018.09.006