The challenge of informed consent: Propensity score weighting to prevent selection bias
Publication date
2026-07
Authors
Frederiks, M. L.
Verhoeven, R. H.A.
van Laarhoven, H. W.M.
Berbée, M.
van Rossum, P S N
Meijer, G J
Rütten, H.
Hartogh, M D den
Nuyttens, J. J.
Wijnhoven, B. P.L.
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Document Type
Article
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Abstract
Informed consent requirements can introduce significant selection bias. This note evaluates prospective versus retrospective consent models and the utility of propensity score weighting to reduce selection bias. While statistical adjustments mitigate the bias, upfront consent frameworks are essential for ensuring unbiased population estimates.
Keywords
Hematology, Oncology, Radiology Nuclear Medicine and imaging
Citation
Frederiks, M L, Verhoeven, R H A, van Laarhoven, H W M, Berbée, M, van Rossum, P S N, Meijer, G J, Rütten, H, Hartogh, M D D, Nuyttens, J J, Wijnhoven, B P L, Langendijk, J A, Schuit, E & Muijs, C T 2026, 'The challenge of informed consent : Propensity score weighting to prevent selection bias', Radiotherapy and Oncology, vol. 220, 111575. https://doi.org/10.1016/j.radonc.2026.111575