Derivatization reactions in the gas—liquid chromatographic analysis of drugs in biological fluids
Publication date
1984
Authors
Hulshoff, A.
Lingeman, H.
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Document Type
Article
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Abstract
Alkylation, acylation, silylation and other derivatization reactions applied to the gas chromatographic analysis of drugs in biological matrices are reviewed. Reaction conditions are discussed in relation to reaction mechanisms. Detector-oriented labelling of drugs, and derivatization with chiral reagents for the separation of enantiomers are surveyed. Data on the sample clean-up, derivatization and GLC analysis of more than 300 drugs and related compounds are listed.
Keywords
Derivatization for gas—liquid chromatography; drug analysis; biological fluids; specific detectors in gas—liquid chromatography;, gas—liquid chromatography—mass spectrometry; sample clean-up procedures