Serologic Detection of Middle East Respiratory Syndrome Coronavirus Functional Antibodies
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Publication date
2020
Authors
Okba, Nisreen M A
Widjaja, Ivy
Li, W.
GeurtsvanKessel, Corine H
Farag, Elmoubasher A B A
Al-Hajri, Mohammed
Park, Wan Beom
Oh, Myoung-Don
Reusken, Chantal B M E
Koopmans, Marion P G
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Document Type
Letter
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Abstract
We developed and validated 2 species-independent protein-based assays to detect Middle East respiratory syndrome coronavirus functional antibodies that can block virus receptor-binding or sialic acid-attachment. Antibody levels measured in both assays correlated strongly with virus-neutralizing antibody titers, proving their use for serologic confirmatory diagnosis of Middle East respiratory syndrome.
Keywords
SDG 3 - Good Health and Well-being
Citation
Okba, N M A, Widjaja, I, Li, W, GeurtsvanKessel, C H, Farag, E A B A, Al-Hajri, M, Park, W B, Oh, M-D, Reusken, C B M E, Koopmans, M P G, Bosch, B-J & Haagmans, B L 2020, 'Serologic Detection of Middle East Respiratory Syndrome Coronavirus Functional Antibodies', Emerging Infectious Diseases, vol. 26, no. 5, pp. 1024-1027. https://doi.org/10.3201/eid2605.190921