Oral tobramycin prophylaxis prior to colorectal surgery is not associated with systemic uptake
Publication date
2018-01-01
Authors
Mulder, Tessa A.M.
Kluytmans-Van Den Bergh, M
Crolla, Rogier M P H
Ermens, A A M
Romme, J
Van'T Veer, Nils E.
Kluytmans, Jan A J W
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Document Type
Article
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Abstract
Preoperative oral prophylaxis with nonabsorbable antibiotics has been reported to reduce the risk of surgical site infections after colorectal surgery. This prospective study was conducted to evaluate the risk of toxic side effects by measuring postoperative serum tobramycin levels in patients who received a 3-day prophylaxis with tobramycin and colistin prior to colorectal surgery. In all patients, serum tobramycin concentrations were below the detection limit (0.3 mg/liter), implying a low risk of toxicity.
Keywords
Antibiotic prophylaxis, Surgery, Tobramycin, Pharmacology, Pharmacology (medical), Infectious Diseases, Journal Article
Citation
Mulder, T, Kluytmans-Van Den Bergh, M F Q, Crolla, R M P H, Ermens, A A M, Romme, J, Van'T Veer, N E & Kluytmans, J A J W 2018, 'Oral tobramycin prophylaxis prior to colorectal surgery is not associated with systemic uptake', Antimicrobial Agents and Chemotherapy, vol. 62, no. 1, e01723. https://doi.org/10.1128/AAC.01723-17