Exposure to polybrominated diphenyl ethers and male reproductive function in Greenland, Poland and Ukraine
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Publication date
2014-01
Authors
Toft, Gunnar
Lenters, Virissa
Vermeulen, R.
Heederik, D.J.J.
Thomsen, Cathrine
Becher, Georg
Giwercman, Aleksander
Bizzaro, Davide
Manicardi, Gian Carlo
Spano, Marcello
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Article
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Abstract
Animal and a few human studies suggest that polybrominated diphenyl ethers (PBDEs) may affect male reproductive function. The aim of the present study was to evaluate if male reproductive function was associated with serum level of PBDEs. We evaluated, in a cross-sectional study, the effects of environmental exposure to BDE-47 and BDE-153 on reproductive hormones and semen quality, including markers of DNA damage and apoptosis, in 299 spouses of pregnant women from Greenland, Poland and Ukraine. Adjusted linear regression models indicated no strong associations between BDE-47 or BDE-153 exposure and markers of male semen quality or reproductive hormones. In the largest study to date we demonstrate that BDE-47 and BDE-153 exposure was not associated with altered semen characteristics or reproductive hormones, indicating that male reproductive function is not affected by the exposure level of these compounds in fertile European or Arctic populations. (C) 2013 Elsevier Inc. All rights reserved.
Keywords
Semen quality, Reproductive hormones, Inhibin B, DNA damage, Apoptosis, PBDE, BDE-47, BDE-153, BROMINATED FLAME RETARDANTS, SPERM CHROMATIN INTEGRITY, IN-HOUSE DUST, SEMEN QUALITY, SERUM-LEVELS, DNA FRAGMENTATION, INUIT POPULATIONS, HORMONE-LEVELS, BIPHENYL PBB, MEN, Coronacrisis-Taverne
Citation
Toft, G, Lenters, V, Vermeulen, R, Heederik, D, Thomsen, C, Becher, G, Giwercman, A, Bizzaro, D, Manicardi, G C, Spano, M, Rylander, L, Pedersen, H S, Strucinski, P, Zviezdai, V & Bonde, J P 2014, 'Exposure to polybrominated diphenyl ethers and male reproductive function in Greenland, Poland and Ukraine', Reproductive Toxicology, vol. 43, pp. 1-7. https://doi.org/10.1016/j.reprotox.2013.10.002