IκBζ: an emerging player in cancer
Publication date
2016-10-04
Authors
Willems, Marie
Dubois, Nadège
Musumeci, Lucia
Bours, Vincent
Robe, Pierre A
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Supervisors
Document Type
Article
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taverne
Abstract
IκBζ, an atypical member of the nuclear IκB family of proteins, is expressed at low levels in most resting cells, but is induced upon stimulation of Toll-like/IL-1 receptors through an IRAK1/IRAK4/NFκB-dependent pathway. Like its homolog Bcl3, IκBζ can regulate the transcription of a set of inflamatory genes through its association with the p50 or p52 subunits of NF-κB. Long studied as a key component of the immune response, IκBζ emerges as an important regulator of inflammation, cell proliferation and survival. As a result, growing evidence support the role of this transcription factor in the pathogenesis number of human hematological and solid malignancies.
Keywords
Animals, Gene Expression Regulation, Neoplastic, Humans, I-kappa B Proteins/genetics, Neoplasms/genetics, Taverne, Review, Journal Article
Citation
Willems, M, Dubois, N, Musumeci, L, Bours, V & Robe, P A 2016, 'IκBζ : an emerging player in cancer', Oncotarget, vol. 7, no. 40, pp. 66310-66322. https://doi.org/10.18632/oncotarget.11624