Principles of Pharmacology and Toxicology Also Govern Effects of Chemicals on the Endocrine System
Publication date
2015-07
Authors
Autrup, Herman
Barile, Frank A.
Blaauboer, Bas J.
Degen, Gisela H.
Dekant, Wolfgang
Dietrich, Daniel
Domingo, Jose L.
Gori, Gio Batta
Greim, Helmuth
Hengstler, Jan G.
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Advisors
Supervisors
Document Type
Article
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taverne
Abstract
The present debate on chemicals with Hormonal activity, often termed 'endocrine disruptors', is highly controversial and includes challenges of the present paradigms used in toxicology and in hazard identification and risk characterization. In our opinion, chemicals with hormonal activity can be subjected to the well-evaluated health risk characterization approach used for many years including adverse outcome pathways. Many of the points arguing for a specific approach for risk characterization of chemicals with hormonal activity are based on highly speculative conclusions. These conclusions are not well supported when evaluating the available information.
Keywords
endocrine disruptors, endocrine toxicology, risk assessment, regulatory/policy, DIETARY 17-BETA-ESTRADIOL E2, HUMAN HEALTH, DISRUPTING CHEMICALS, RISK-ASSESSMENT, BISPHENOL-A, MYCOTOXIN ZEARALENONE, REPRODUCTIVE TOXICITY, FEMALE MICE, SWISS MICE, IN-UTERO, Taverne, SDG 3 - Good Health and Well-being
Citation
Autrup, H, Barile, F A, Blaauboer, B J, Degen, G H, Dekant, W, Dietrich, D, Domingo, J L, Gori, G B, Greim, H, Hengstler, J G, Kacew, S, Marquardt, H, Pelkonen, O, Savolainen, K & Vermeulen, N P 2015, 'Principles of Pharmacology and Toxicology Also Govern Effects of Chemicals on the Endocrine System', Toxicological Sciences, vol. 146, no. 1, pp. 11-15. https://doi.org/10.1093/toxsci/kfv082