Platelet Inhibition by Insulin Is Absent in Type 2 Diabetes Mellitus
Publication date
2006
Authors
Haeften, T.W. van
Akkerman, Jan Willem N.
Heemskerk, J.W.
Gorter, G.
Feijge, M.A.
Mocking, A.I.M.
Ferreira, I.A.
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DOI
Document Type
Article
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Abstract
Objective—ADP-induced P2y12 signaling is crucial for formation and stabilization of an arterial thrombus. We demonstrated recently in platelets from healthy subjects that insulin interferes with Ca2+ increases induced by ADP-P2y1 contact through blockade of the G-protein Gi, and thereby with P2y12-mediated suppression of cAMP.
Keywords
P2y12 receptor, Ca2+ regulation, clopidogrel, protein kinase B/Akt, IRS-1