Functional Limitations in Severe Haemophilia

Abstract

This thesis aims to describe the Disablement Process (DP) in Dutch adult patients with severe haemophilia, with specific focus on the domain of “Functional Limitations”. Four main questions underlie this thesis:

How can Functional Limitations in severe haemophilia be investigated? Can the Disablement Process, as a research model, yield clinically relevant results? What variables are associated with Functional Limitations? What is the role of Functional Limitations within the whole process of disablement?

Two main topics are presented: [1] the development of a haemophilia specific self-assessment questionnaire to address the patient's perception on functional abilities and [2] several investigations within the framework of the DP.