Serum inflammatory mediators correlate with disease activity in electrical status epilepticus in sleep (ESES) syndrome
Files
Publication date
2016-02
Authors
Van Den Munckhof, Bart
de Vries, Evelien E.
Braun, Kees P J
Boss, H. Myrthe
Willemsen, Michèl A
van Royen, Annet
de Jager, Wilco
Jansen, Floor E.
Editors
Advisors
Supervisors
Document Type
Article
Metadata
Show full item recordCollections
License
taverne
Abstract
We aimed to study serum cytokine levels in 11 electrical status epilepticus in sleep (ESES) patients and 20 healthy control children. Patients showed significantly higher levels of interleukin (IL)-1α, IL-6, IL-10, chemokine (C-C motif) ligand (CCL)2 and chemokine (C-X-C motif) ligand (CXCL)8/IL-8 than controls, while macrophage migration inhibitory factor (MIF) and CCL3 were significantly lower. Follow-up analyses in five patients revealed a significant decrease of IL-6 levels after immunomodulating treatment. IL-6 changes were accompanied by clear improvement of electroencephalography (EEG) patterns and neuropsychological evaluation. We hypothesize that IL-6 correlates with disease activity and immunomodulating treatment efficacy.
Keywords
Cytokines, Electrical status epilepticus during sleep, ESES, Continuous spikes and waves during sleep, CSWS, Landau-Kleffner syndrome, Taverne, Journal Article, Research Support, Non-U.S. Gov't
Citation
van den Munckhof, B, de Vries, E E, Braun, K P J, Boss, H M, Willemsen, M A, van Royen, A, de Jager, W & Jansen, F E 2016, 'Serum inflammatory mediators correlate with disease activity in electrical status epilepticus in sleep (ESES) syndrome', Epilepsia, vol. 57, no. 2, pp. e45–e50. https://doi.org/10.1111/epi.13274