Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma
Publication date
2017
Authors
Bernatsky, Sasha
Velásquez García, Héctor A
Spinelli, John
Gaffney, Patrick
Smedby, Karin E
Ramsey-Goldman, Rosalind
Wang, Sophia S.
Adami, Hans-Olov
Albanes, Demetrius
Angelucci, Emanuele
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Abstract
Objective: Determinants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are unclear. Using data from a recent lymphoma genome-wide association study (GWAS), we assessed whether certain lupus-related single nucleotide polymorphisms (SNPs) were also associated with DLBCL. Methods: GWAS data on European Caucasians from the International Lymphoma Epidemiology Consortium (InterLymph) provided a total of 3857 DLBCL cases and 7666 general-population controls. Data were pooled in a random-effects meta-analysis. Results: Among the 28 SLE-related SNPs investigated, the two most convincingly associated with risk of DLBCL included the CD40 SLE risk allele rs4810485 on chromosome 20q13 (OR per risk allele=1.09, 95% CI 1.02 to 1.16, p=0.0134), and the HLA SLE risk allele rs1270942 on chromosome 6p21.33 (OR per risk allele=1.17, 95% CI 1.01 to 1.36, p=0.0362). Of additional possible interest were rs2205960 and rs12537284. The rs2205960 SNP, related to a cytokine of the tumour necrosis factor superfamily TNFSF4, was associated with an OR per risk allele of 1.07, 95% CI 1.00 to 1.16, p=0.0549. The OR for the rs12537284 (chromosome 7q32, IRF5 gene) risk allele was 1.08, 95% CI 0.99 to 1.18, p=0.0765. Conclusions: These data suggest several plausible genetic links between DLBCL and SLE.
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Bernatsky, S, Velásquez García, H A, Spinelli, J, Gaffney, P, Smedby, K E, Ramsey-Goldman, R, Wang, S S, Adami, H-O, Albanes, D, Angelucci, E, Ansell, S M, Asmann, Y W, Becker, N, Benavente, Y, Berndt, S I, Bertrand, K A, Birmann, B M, Boeing, H, Boffetta, P, Bracci, P M, Brennan, P, Brooks-Wilson, A R, Cerhan, J R, Chanock, S J, Clavel, J, Conde, L, Cotenbader, K H, Cox, D G, Cozen, W, Crouch, S, De Roos, A J, De Sanjose, S, Di Lollo, S, Diver, W R, Dogan, A, Foretova, L, Ghesquières, H, Giles, G G, Glimelius, B, Habermann, T M, Haioun, C, Hartge, P, Hjalgrim, H, Holford, T R, Holly, E A, Jackson, R D, Kaaks, R, Kane, E, Kelly, R S, Klein, R J, Kraft, P, Kricker, A, Lan, Q, Lawrence, C, Liebow, M, Lightfoot, T, Link, B K, Maynadie, M, McKay, J, Melbye, M, Molina, T J, Monnereau, A, Morton, L M, Nieters, A, North, K E, Novak, A J, Offit, K, Purdue, M P, Rais, M, Riby, J, Roman, E, Rothman, N, Salles, G, Severi, G, Severson, R K, Skibola, C F, Slager, S L, Smith, A, Smith, M T, Southey, M C, Staines, A, Teras, L R, Thompson, C A, Tilly, H, Tinker, L F, Tjonneland, A, Turner, J, Vajdic, C M, Vermeulen, R C H, Vijai, J, Vineis, P, Virtamo, J, Wang, Z, Weinstein, S, Witzig, T E, Zelenetz, A, Zeleniuch-Jacquotte, A, Zhang, Y, Zheng, T, Zucca, M & Clarke, A E 2017, 'Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma', Lupus Science and Medicine, vol. 4, no. 1, e000187. https://doi.org/10.1136/lupus-2016-000187