Cancer-ID: towards identification of cancer by tumor-derived extracellular vesicles in blood
Publication date
2020-06
Authors
Rikkert, L G
Beekman, P
Caro, J
Coumans, F A W
Enciso Martinez, A
Jenster, G
Le Gac, S
Lee, W
Van Leeuwen, Ton G
Loozen, G B
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Document Type
Article
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Abstract
Extracellular Vesicles (EVs) have great potential as biomarkers since their composition and concentration in biofluids are disease state-dependent and their cargo can contain disease related information. Large tumor-derived EVs (tdEVs, > 1 μm) in blood from cancer patients are associated with poor outcome and changes in their number can be used to monitor therapy effectiveness. Whereas small tumor-derived EVs (
Keywords
Atomic Force Microscopy, Cell-Derived Microparticles, Electrochemistry, Exosomes, Flow Cytometry, Raman spectrum analysis, Scanning electron microscopy, Surface Plasmon Resonance, extracellular vesicles, fluorescence microscopy, transmission electron microscopy 3, SDG 3 - Good Health and Well-being
Citation
Rikkert, L G, Beekman, P, Caro, J, Coumans, F A W, Enciso Martinez, A, Jenster, G, Le Gac, S, Lee, W, Van Leeuwen, T G, Loozen, G B, Nanou, A, Nieuwland, R, Offerhaus, H L, Otto, C, Pegtel, D M, Piontek, M C, Van Der Pol, E, De Rond, L, Roos, W H, Schasfoort, R B M, Wauben, M, Zuilhof, H & Terstappen, L WMM 2020, 'Cancer-ID: towards identification of cancer by tumor-derived extracellular vesicles in blood', Frontiers in Oncology, vol. 10, 608. https://doi.org/10.3389/FONC.2020.00608