Considerations in the search for epistasis
Publication date
2024-11-19
Authors
Lorentz workshop on epistasis
Balvert, Marleen
Cooper-Knock, Johnathan
Stamp, Julian
Byrne, Ross P.
Mourragui, Soufiane
van Gils, Juami
Benonisdottir, Stefania
Schlüter, Johannes
Kenna, Kevin
Editors
Advisors
Supervisors
Document Type
Article
Metadata
Show full item recordCollections
License
Abstract
Epistasis refers to changes in the effect on phenotype of a unit of genetic information, such as a single nucleotide polymorphism or a gene, dependent on the context of other genetic units. Such interactions are both biologically plausible and good candidates to explain observations which are not fully explained by an additive heritability model. However, the search for epistasis has so far largely failed to recover this missing heritability. We identify key challenges and propose that future works need to leverage idealized systems, known biology and even previously identified epistatic interactions, in order to guide the search for new interactions.
Keywords
Ecology, Evolution, Behavior and Systematics, Genetics, Cell Biology
Citation
Lorentz workshop on epistasis, Balvert, M, Cooper-Knock, J, Stamp, J, Byrne, R P, Mourragui, S, van Gils, J, Benonisdottir, S, Schlüter, J, Kenna, K, Abeln, S, Iacoangeli, A, Daub, J T, Browning, B L, Taş, G, Hu, J, Wang, Y, Alhathli, E, Harvey, C, Pianesi, L, Schulte, S C, González-Domínguez, J, Garrisson, E, Pasanuic, B, Zhang, S, Vorbrugg, S, van Bemmelen, J, Dandinasivara, R, Markowska, M, Koyuturk, M, Guarracino, A, Bonizzoni, P, Bolognini, D, von Berg, J, Baaijens, J, Cartes, J A, Al-Chalabi, A, Snyder, M P, Schönhuth, A, Sng, L M F & Twine, N A 2024, 'Considerations in the search for epistasis', Genome Biology, vol. 25, no. 1, 296. https://doi.org/10.1186/s13059-024-03427-z