Kidney Function and the Risk of Stroke and Dementia: The Rotterdam Study
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Publication date
2019
Authors
Koop-Nieuwelink, Carolien
Sedaghat, Sanaz
Mutlu, Unal
Licher, Silvan
Franco, Oscar H
Ikram, M Arfan
Geerlings, M.
Ikram, M. Arfan
Bos, Daniel
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Document Type
Article
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taverne
Abstract
Longitudinal population-based data on effects of kidney dysfunction in the development of stroke and dementia remains inconclusive. We investigated associations of kidney function with risk of stroke and dementia in 5,993 community-dwelling individuals (mean age: 69.0 years, 57.2% women). We calculated estimated glomerular filtration rates based on creatinine, cystatin-C, and a combination of these two. During a mean follow-up of 11.6 years (69,790 person-years), 1,360 individuals suffered a stroke (n = 601) or developed dementia (n = 759). We found that an impaired kidney function was related to a higher risk of stroke, but not to dementia.
Keywords
Dementia, epidemiology, glomerular filtration rate, kidney function, stroke, Taverne, Journal Article
Citation
Koop-Nieuwelink, C, Sedaghat, S, Mutlu, U, Licher, S, Franco, O H, Ikram, M A, Geerlings, M I, Ikram, M K & Bos, D 2019, 'Kidney Function and the Risk of Stroke and Dementia : The Rotterdam Study', Journal of Alzheimer's Disease, vol. 67, no. 3, pp. 821-826. https://doi.org/10.3233/JAD-181086