Converging biofabrication and organoid technologies: The next frontier in hepatic and intestinal tissue engineering?
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Publication date
2017-03-01
Authors
Schneeberger, Kerstin
Spee, Bart
Costa, Pedro
Sachs, Norman
Clevers, Hans
Malda, Jos
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Document Type
Article
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taverne
Abstract
Adult tissue stem cells can form self-organizing 3D organoids in vitro. Organoids resemble small units of their organ of origin and have great potential for tissue engineering, as well as models of disease. However, current culture technology limits the size, architecture and complexity of organoids. Here, we review the establishment of intestinal and hepatic organoids and discuss how the convergence of organoids and biofabrication technologies can help overcome current limitations, and thereby further advance the translational application of organoids in tissue engineering and regenerative medicine.
Keywords
bioprinting, organoids, regenerative medicine, tissue engineering, vascularization, Taverne, Biotechnology, Bioengineering, Biochemistry, Biomaterials, Biomedical Engineering, Journal Article
Citation
Schneeberger, K, Spee, B, Costa, P, Sachs, N, Clevers, H & Malda, J 2017, 'Converging biofabrication and organoid technologies : The next frontier in hepatic and intestinal tissue engineering?', Biofabrication, vol. 9, no. 1, 013001. https://doi.org/10.1088/1758-5090/aa6121