Prolonged carriage and potential onward transmission of carbapenemase-producing Enterobacteriaceae in Dutch travelers
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Publication date
2016-07
Authors
van Hattem, Jarne M
Arcilla, Maris S
Bootsma, M.
van Genderen, Perry J
Goorhuis, Abraham
Grobusch, Martin P
Molhoek, Nicky
Oude Lashof, Astrid Ml
Schultsz, Constance
Stobberingh, Ellen E
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Abstract
AIM: The aim was to study acquisition and persistence of carbapenemase-producing Enterobacteriaceae (CPE) among travelers. MATERIALS & METHODS: Stools from 2001 travelers and 215 nontraveling household members, collected before and immediately post-travel as well as 1, 3, 6 and 12 months upon return, were screened for CPE. RESULTS: Five travelers, all visiting Asia outside the Indian subcontinent, acquired CPE. One traveler persistently carried the same OXA-244 CPE up to 6 months post-travel. Three months after travel, her co-traveling spouse also became positive for this OXA-244 CPE strain, suggesting clonal transmission within this household. CONCLUSION: Acquisition of CPE is not restricted to travelers to the Indian subcontinent and/or to travelers seeking healthcare during travel and can persist up to at least 6 months post-travel.
Keywords
carbapenemases, Enterobacteriaceae, transmission, travel
Citation
van Hattem, J M, Arcilla, M S, Bootsma, M C, van Genderen, P J, Goorhuis, A, Grobusch, M P, Molhoek, N, Oude Lashof, A M, Schultsz, C, Stobberingh, E E, Verbrugh, H A, de Jong, M D, Melles, D C & Penders, J 2016, 'Prolonged carriage and potential onward transmission of carbapenemase-producing Enterobacteriaceae in Dutch travelers', Future Microbiology, vol. 11, pp. 857-64. https://doi.org/10.2217/fmb.16.18