Model organoids provide new research opportunities for ductal pancreatic cancer
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Publication date
2016-01
Authors
Boj, Sylvia F
Hwang, Chang-Il
Baker, Lindsey A
Engle, Dannielle D
Tuveson, David A
Clevers, Hans
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Document Type
Article
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Abstract
We recently established organoid models from normal and neoplastic murine and human pancreas tissues. These organoids exhibit ductal- and disease stage-specific characteristics and, after orthotopic transplantation, recapitulate the full spectrum of tumor progression. Pancreatic organoid technology provides a novel platform for the study of tumor biology and the discovery of potential biomarkers, therapeutics, and personalized medicine strategies.
Keywords
cancer, pancreatic ductal adenocarcinoma, organoids, preclinical models, Journal Article
Citation
Boj, S F, Hwang, C-I, Baker, L A, Engle, D D, Tuveson, D A & Clevers, H 2016, 'Model organoids provide new research opportunities for ductal pancreatic cancer', Molecular and Cellular Oncology , vol. 3, no. 1, e1014757. https://doi.org/10.1080/23723556.2015.1014757