Prognostic factors for wilms tumor recurrence: A review of the literature
Publication date
2021-07-01
Authors
Groenendijk, Alissa
Spreafico, Filippo
de Krijger, Ronald
Drost, Jarno
Brok, Jesper
Perotti, Daniela
van Tinteren, Harm
Venkatramani, Rajkumar
Godziński, Jan
Rübe, Christian
Editors
Advisors
Supervisors
Document Type
Article
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cc_by
Abstract
In high-income countries, the overall survival of children with Wilms tumors (WT) is ~90%. However, overall, 15% of patients experience tumor recurrence. The adverse prognostic factors currently used for risk stratification (advanced stage, high risk histology, and combined loss of heterozygosity at 1p and 16q in chemotherapy-naïve WTs) are present in only one third of these cases, and the significance of these factors is prone to change with advancing knowledge and improved treatment regimens. Therefore, we present a comprehensive, updated overview of the pub-lished prognostic variables for WT recurrence, ranging from patient-, tumor-and treatment-related characteristics to geographic and socioeconomic factors. Improved first-line treatment regimens based on clinicopathological characteristics and advancing knowledge on copy number variations unveil the importance of further investigating the significance of biological markers for WT recurrence in international collaborations.
Keywords
Pediatric, Prognosis, Recurrence, Wilms tumor, Oncology, Cancer Research
Citation
Groenendijk, A, Spreafico, F, de Krijger, R R, Drost, J, Brok, J, Perotti, D, van Tinteren, H, Venkatramani, R, Godziński, J, Rübe, C, Geller, J I, Graf, N, van den Heuvel-Eibrink, M M & Mavinkurve-Groothuis, A M C 2021, 'Prognostic factors for wilms tumor recurrence : A review of the literature', Cancers, vol. 13, no. 13, 3142, pp. 1-25. https://doi.org/10.3390/cancers13133142