Hereditary Colorectal Cancer: Genetics and Screening
Publication date
2015-10
Authors
Brosens, Lodewijk A
Offerhaus, G. Johan
Giardiello, Francis M.
Editors
Advisors
Supervisors
Document Type
Article
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taverne
Abstract
Colorectal cancer (CRC) is the third most common cancer and the third leading cause of cancer death in men and women in the United States. About 30% of patients with CRC report a family history of CRC. However, only 5% of CRCs arise in the setting of a well-established mendelian inherited disorder. In addition, serrated polyposis is a clinically defined syndrome with multiple serrated polyps in the colorectum and an increased CRC risk for which the genetics are unknown. This article focuses on genetic and clinical aspects of Lynch syndrome, familial adenomatous polyposis, and MUTYH-associated polyposis.
Keywords
Colorectal cancer, Familial adenomatous polyposis, Hereditary nonpolyposis colorectal cancer, Lynch syndrome, MUTYH-associated polyposis, Taverne, Surgery, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review
Citation
Brosens, L A A, Offerhaus, G J A & Giardiello, F M 2015, 'Hereditary Colorectal Cancer : Genetics and Screening', Surgical Oncology Clinics of North America, vol. 95, no. 5, pp. 1067-1080. https://doi.org/10.1016/j.suc.2015.05.004