Author Correction: Whole genome sequencing of metastatic colorectal cancer reveals prior treatment effects and specific metastasis features (Nature Communications, (2021), 12, 1, (574), 10.1038/s41467-020-20887-6)

Publication date

2021-05-26

Authors

Mendelaar, Pauline A.J.
Smid, Marcel
van Riet, Job
Angus, Lindsay
Labots, Mariette
Steeghs, NeeltjeORCID 0000-0003-2989-2279
Hendriks, Mathijs P.
Cirkel, Geert A
van Rooijen, Johan M.
Ten Tije, Albert J.

Editors

Advisors

Supervisors

Document Type

Comment

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cc_by

Abstract

The original version of this Article contained an error in Table 4, in which the coefficients of the LASSO regression model of treatment response corresponded to a version that was performed without non-coding genes. The new version of the table, which was generated during revision of the manuscript, contains the coefficients that were obtained after including potential non-coding driver genes in the model. Genomic features that became statistically significant after re-running the model were also added, which included: ‘nr of 10 kb–1Mb deletions’, ‘SBS41’, ‘Non-coding - LINC00672’, ‘Gain 7p12.3 - (PKD1L1)’, ‘Loss 4q22.1 - (CCSER1)’, and ‘Loss 18q23 - (NFATC1*)’. This has now been corrected in both the PDF and HTML versions of the Article. The original version of this Article also contained an error in the author affiliations. The affiliations of Job van Riet with Cancer Computational Biology Center, Erasmus MC Cancer Institute, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands and Department of Urology, Erasmus MC Cancer Institute, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands were inadvertently omitted. This has now been corrected in both the PDF and HTML versions of the Article. The original version of this Article contained an error in the Methods, section “Whole-genome sequencing; identification of somatic changes”, which incorrectly read ‘GATK BQSR and Haplotype Caller v3.4.46 were used to call somatic mutations.’ The correct version is ‘GATK BQSR and Haplotype Caller v3.4.46 and Strelka v1.0.14 were used to call somatic mutations’. This has been corrected in both the PDF and HTML versions of the Article.

Keywords

General Chemistry, General Biochemistry,Genetics and Molecular Biology, General Physics and Astronomy

Citation

Mendelaar, P A J, Smid, M, van Riet, J, Angus, L, Labots, M, Steeghs, N, Hendriks, M P, Cirkel, G A, van Rooijen, J M, Ten Tije, A J, Lolkema, M P, Cuppen, E, Sleijfer, S, Martens, J W M & Wilting, S M 2021, 'Author Correction : Whole genome sequencing of metastatic colorectal cancer reveals prior treatment effects and specific metastasis features (Nature Communications, (2021), 12, 1, (574), 10.1038/s41467-020-20887-6)', Nature Communications, vol. 12, no. 1, 3269. https://doi.org/10.1038/s41467-021-23629-4