Cryptococcus neoformans and neutrophil migration

Abstract

This thesis has focused on several aspects of cryptococcal glucuronoxylomannan (GXM)-related interference with neutrophil migration into inflammatory sites. First, the effect of GXM on neutrophil adhesion (rolling and firm adhesion) to the endothelium was investigated and potential mechanisms were explored. Second, we investigated the outcome of GXM treatment on neutrophil recruitment in a model of myocardial ischemia. Finally, we examined the role of certain structural elements of GXM in the effects on neutrophil migration.