New 2030 Global Targets for Histoplasmosis from International Society for Human and Animal Mycology (ISHAM) 2025 Histoplasmosis Working Group
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Publication date
2026-03
Authors
Pasqualotto, Alessandro C
Denning, David W
Govender, Nelesh P
Hagen, Ferry
Zancope-Oliveira, Rosely M
Caceres, Diego H
Francoise, Ugo
Guimaraes, Allan
Damasceno, Lisandra S
Falci, Diego R
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Document Type
Article
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Abstract
Histoplasmosis remains a neglected yet deadly fungal infection, disproportionately affecting persons living with HIV/AIDS and other immunocompromised populations in endemic regions. Despite the World Health Organization's designation of Histoplasma as a high-priority pathogen, the disease remains underdiagnosed and excluded from national surveillance systems, resulting in delayed treatment and high death rates. To coordinate a global response, the International Society for Human and Animal Mycology convened a Histoplasmosis Working Group during its 2025 congress in Brazil. Experts engaged in structured discussions across 5 domains: awareness, research, diagnostics and treatment, capacity building, and fungal biology. The group highlighted persistent diagnostic delays, underuse of antigen testing, and poor access to liposomal amphotericin B and itraconazole. Innovations such as lateral flow assays and molecular tools were discussed, alongside the need for biobanks and validated diagnostic algorithms. A global 90-90-90 target for histoplasmosis by 2030 was proposed to improve diagnosis, treatment, and survival.
Keywords
Animals, Antifungal Agents/therapeutic use, Global Health, Histoplasma, Histoplasmosis/diagnosis, Humans, Journal Article
Citation
Pasqualotto, A C, Denning, D W, Govender, N P, Hagen, F, Zancope-Oliveira, R M, Caceres, D H, Francoise, U, Guimaraes, A, Damasceno, L S, Falci, D R, Gomez, B L, Schwartz, I, Vidal, J E, Galan, L E, Xavier, M O, Nacher, M, Effron, G G, Brown, G, Barros, N, Godoy, C M, Fraga, T, Soares, R B A, Severo, C B, Schwarzbold, A V, Berrio, I, de Melo, M G, Reis, N, Tenorio, B G, Leitao, T M J, Bastos, C J D C, Bay, M B, de Lacerda, M V G, Bazana, L C G, Lana, D F D, Vieceli, T, Riche, C V W, Arathoon, E, Canteros, C, Boulware, D, Alastruey-Izquierdo, A, Oladele, R, Teixeira, M D M, Colombo, A L, Perez, F M, Chiller, T, Bahr, N C, Tudela, J L R & Adenis, A 2026, 'New 2030 Global Targets for Histoplasmosis from International Society for Human and Animal Mycology (ISHAM) 2025 Histoplasmosis Working Group', Emerging infectious diseases, vol. 32, no. 3, pp. 1-9. https://doi.org/10.3201/eid3203.251165