Inhibition of secretion by asexual reproduction in Aspergillus niger

Abstract

The aim of this Thesis was to study mechanism involved in zonal secretion in colonies of A. niger with emphasis on sporulation inhibited secretion. These mechanisms may be targets to improve A. nigeras a cell factory. I focused in particular on A. niger homologues of fluG and veA that are known sporulation genes in A. nidulans. Moreover, I studied the role of light because asexual reproduction is known to occur mainly in the light in A. nidulans. This suggests that sporulation and, as a consequence of this, secretion are influenced by light in A. niger.