Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: Results from the EPIC cohort
Publication date
2015-01-01
Authors
Ose, J.
Fortner, R. T.
Schock, H.
Peeters, Petra H.
Onland-Moret, N. Charlotte
Bueno-De-Mesquita, H. Bas
Weiderpass, E.
Gram, I. T.
Overvad, K.
Tjonneland, A.
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Advisors
Supervisors
Document Type
Article
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Abstract
Background: Prospective studies on insulin-like growth factor I (IGF-I) and epithelial ovarian cancer (EOC) risk are inconclusive. Data suggest risk associations vary by tumour characteristics. Methods: We conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate IGF-I concentrations and EOC risk by tumour characteristics (n=565 cases). Multivariable conditional logistic regression models were used to estimate associations. Results: We observed no association between IGF-I and EOC overall or by tumour characteristics. Conclusions: In the largest prospective study to date was no association between IGF-I and EOC risk. Pre-diagnostic serum IGF-I concentrations may not influence EOC risk.
Keywords
carcinogenesis, dualistic pathway, histological subtypes, IGF-I, ovarian cancer, type I/type II, Cancer Research, Oncology, General Medicine
Citation
Ose, J, Fortner, R T, Schock, H, Peeters, P H, Onland-Moret, N C, Bueno-De-Mesquita, H B, Weiderpass, E, Gram, I T, Overvad, K, Tjonneland, A, Dossus, L, Fournier, A, Baglietto, L, Trichopoulou, A, Benetou, V, Trichopoulos, D, Boeing, H, Masala, G, Krogh, V, Matiello, A, Tumino, R, Popovic, M, Obón-Santacana, M, Larrañaga, N, Ardanaz, E, Sánchez, M J, Menéndez, V, Chirlaque, M D, Travis, R C, Khaw, K T, Brändstedt, J, Idahl, A, Lundin, E, Rinaldi, S, Kuhn, E, Romieu, I, Gunter, M J, Merritt, M A, Riboli, E & Kaaks, R 2015, 'Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics : Results from the EPIC cohort', British Journal of Cancer, vol. 112, no. 1, pp. 162-166. https://doi.org/10.1038/bjc.2014.566