The need for precision medicine clinical trials in childhood asthma: rationale and design of the PUFFIN trial
Publication date
2017-03
Authors
Vijverberg, Susanne J H
Pijnenburg, Mariëlle W
Hövels, Anke
Koppelman, Gerard H
Maitland - van der Zee, Anke-Hilse
Editors
Advisors
Supervisors
Document Type
Article
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License
taverne
Abstract
A 'one-size fits all'-approach does not fit all pediatric asthma patients. Current evidence suggests that in children with persistent asthma, ADRB2 genotype-guided treatment can improve treatment outcomes, yet this evidence is mainly derived from observational and genotype-stratified studies. Implementation of precision medicine-guided asthma treatment in clinical practice will only occur if randomized clinical trials can show that this approach will improve patient outcomes and is cost effective. In this paper, we will discuss why precision medicine trials are currently needed to improve childhood asthma management and present the rationale and design of the PUFFIN trial, that has been set up to address this need.
Keywords
Asthma, Child, Double-Blind Method, Humans, Multicenter Studies as Topic, Precision Medicine, Randomized Controlled Trials as Topic, Receptors, Adrenergic, beta-2, Journal Article, Review, Taverne, SDG 3 - Good Health and Well-being
Citation
Vijverberg, S J, Pijnenburg, M W, Hövels, A M, Koppelman, G H & Maitland-van der Zee, A-H 2017, 'The need for precision medicine clinical trials in childhood asthma : rationale and design of the PUFFIN trial', Pharmacogenomics, vol. 18, no. 4, pp. 393-401. https://doi.org/10.2217/pgs-2016-0174