Limited CD4 T-cell renewal in early HIV-1 infection : effect of highly active antiretroviral therapy
Publication date
1998
Authors
Fleury, S.
Boer, R.J. de
Rizzard, G.J.
Wolthers, K.C.
Otto, S.A.
Welbon, C.C.
Graziosi, C.
Knabenhans, C.
Soudeyns, H.
Bart, P.A.
Editors
Advisors
Supervisors
Document Type
Article
Metadata
Show full item recordCollections
License
Abstract
We show that the fraction of proliferating CD4+ lymphocytes is similar in HIV-infected subjects in the early stage of disease and in HIV-negative subjects, whereas the fraction of proliferating CD8+ lymphocytes is increased 6.8-fold in HIV-infected subjects. After initiation of antiviral therapy, there is a late increase in proliferating CD4+ T cells associated with the restoration of CD4+ T-cell counts. These results provide strong support for the idea of limited CD4+ T-cell renewal in the early stage of HIV infection and indicate that after effective suppression of virus replication, the mechanisms of CD4+ T-cell production are still functional in early HIV infection.