Organoid-based modeling of intestinal development, regeneration, and repair
Publication date
2021-01
Authors
Sprangers, Joep
Zaalberg, Irene C.
Maurice, Madelon M
Editors
Advisors
Supervisors
Document Type
Article
Metadata
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License
cc_by
Abstract
The intestinal epithelium harbors a remarkable adaptability to undergo injury-induced repair. A key part of the regenerative response is the transient reprogramming of epithelial cells into a fetal-like state, which drives uniform proliferation, tissue remodeling, and subsequent restoration of the homeostatic state. In this review, we discuss how Wnt and YAP signaling pathways control the intestinal repair response and the transitioning of cell states, in comparison with the process of intestinal development. Furthermore, we highlight how organoid-based applications have contributed to the characterization of the mechanistic principles and key players that guide these developmental and regenerative events.
Keywords
Adult, Animals, Epithelial Cells/metabolism, Homeostasis, Humans, Intestinal Mucosa/metabolism, Intestines/cytology, Organoids/cytology, Regeneration/physiology, Wnt Signaling Pathway, YAP-Signaling Proteins, Journal Article, Research Support, Non-U.S. Gov't, Review
Citation
Sprangers, J, Zaalberg, I C & Maurice, M M 2021, 'Organoid-based modeling of intestinal development, regeneration, and repair', Cell Death and Differentiation, vol. 28, no. 1, pp. 95-107. https://doi.org/10.1038/s41418-020-00665-z