Prospective comparative study of MRI including diffusion-weighted images versus FDG PET-CT for the detection of recurrent head and neck squamous cell carcinomas after (chemo)radiotherapy
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Publication date
2019-02-01
Authors
Driessen, Juliette P
Peltenburg, Boris
Philippens, Mariëlle E P
Huijbregts, Julia E.
Pameijer, Frank A
de Bree, Remco
Janssen, LM
Terhaard, Chris H.J.
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Article
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taverne
Abstract
Objective: This prospective study aims to test if MRI including diffusion weighted images can replace FDG PET-CT in the diagnosis of patients with suspicion of local recurrent head and neck squamous cell carcinomas after (chemo)radiation. Methods: Seventy-five patients suspected of local recurrence underwent a MRI and a FDG PET-CT. Qualitative assessment of the images was performed. Reference standard was the results of biopsy or the absence of a recurrence during follow up. Results: Seventy patients were included. Fifty percent had local recurrence. FDG PET-CT had accuracy of 71% compared to 73% for MRI. The sensitivity and specificity were 97% compared to 69% and 46% compared to 77% for FDG PET-CT and MRI respectively. Conclusions: MRI showed similar diagnostic accuracy, superior specificity but inferior sensitivity compared to FDG PET-CT. Based on current results, we consider MRI including diffusion weighted sequences unable to replace FDG PET-CT as a single imaging modality when local recurrent disease of HNSCC after (C)RT is suspected.
Keywords
Chemoradiotherapy, Diffusion magnetic resonance imaging, Head and neck neoplasms, Neoplasm recurrence, Positron emission tomography computed tomography, Neoplasm Recurrence, Local/diagnostic imaging, Prospective Studies, Humans, Middle Aged, Male, Squamous Cell Carcinoma of Head and Neck/diagnostic imaging, Aged, 80 and over, Adult, Female, Fluorodeoxyglucose F18, Aged, Diffusion Magnetic Resonance Imaging/methods, Positron Emission Tomography Computed Tomography/methods, Taverne, Radiology Nuclear Medicine and imaging, Journal Article, Comparative Study
Citation
Driessen, J P, Peltenburg, B, Philippens, M E P, Huijbregts, J E, Pameijer, F A, de Bree, R, Janssen, L M & Terhaard, C H J 2019, 'Prospective comparative study of MRI including diffusion-weighted images versus FDG PET-CT for the detection of recurrent head and neck squamous cell carcinomas after (chemo)radiotherapy', European Journal of Radiology, vol. 111, pp. 62-67. https://doi.org/10.1016/j.ejrad.2018.12.004