Malignant progression of Barrett's esophagus: pathogenesis, surveillance and follow-up

Abstract

This thesis demonstrated novel insights in the genetic and environmental contribution to the development of BE and EAC. Accordingly, the effect of surveillances strategies for BE on EAC progression risk and mortality, and the efficacy of follow-up strategies in BE-associated neoplasia were elucidated. Altogether, for the best of patient interest, these results importantly contribute to optimizing current surveillance and follow-up strategies in BE in order to reduce progression towards EAC.