GFAP Alternative Splicing and the Relevance for Disease - A Focus on Diffuse Gliomas
Publication date
2022-06-09
Authors
van Asperen, Jessy V.
Robe, Pierre A J T
Hol, Elly
Editors
Advisors
Supervisors
Document Type
Article
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License
cc_by_nc
Abstract
Glial fibrillary acidic protein (GFAP) is an intermediate filament protein that is characteristic for astrocytes and neural stem cells, and their malignant analogues in glioma. Since the discovery of the protein 50 years ago, multiple alternative splice variants of the GFAP gene have been discovered, leading to different GFAP isoforms. In this review, we will describe GFAP isoform expression from gene to protein to network, taking the canonical isoforms GFAPα and the main alternative variant GFAPδ as the starting point. We will discuss the relevance of studying GFAP and its isoforms in disease, with a specific focus on diffuse gliomas.
Keywords
Alternative Splicing/genetics, Astrocytes/metabolism, Glial Fibrillary Acidic Protein/genetics, Glioma/genetics, Humans, Intermediate Filaments/metabolism, Protein Isoforms/genetics, cytoskeleton, glia, GFAP, glioma, splicing, astrocyte, Clinical Neurology, General Neuroscience, Review, Research Support, Non-U.S. Gov't, Journal Article
Citation
van Asperen, J V, Robe, P A J T & Hol, E M 2022, 'GFAP Alternative Splicing and the Relevance for Disease - A Focus on Diffuse Gliomas', ASN neuro, vol. 14, pp. 1-18. https://doi.org/10.1177/17590914221102065