Reassortments among Avian Influenza A(H5N1) Viruses Circulating in Indonesia, 2015-2016
Publication date
2019
Authors
Karo-Karo, Desniwaty
Bodewes, Rogier
Wibawa, Hendra
Artika, Made
Pribadi, Eko Sugeng
Diyantoro, D
Pratomo, Widya
Sugama, Agus
Hendrayani, Nani
Indasari, Iin
Editors
Advisors
Supervisors
Document Type
Article
Metadata
Show full item recordCollections
License
Abstract
Highly pathogenic avian influenza (HPAI) A(H5N1) viruses have been circulating since 2003 in Indonesia, with major impacts on poultry health, severe economic losses, and 168 fatal laboratory-confirmed human cases. We performed phylogenetic analysis on 39 full-genome H5N1 virus samples collected during outbreaks among poultry in 2015-2016 in West Java and compared them with recently published sequences from Indonesia. Phylogenetic analysis revealed that the hemagglutinin gene of all samples belonged to 2 genetic groups in clade 2.3.2.1c. We also observed these groups for the neuraminidase, nucleoprotein, polymerase, and polymerase basic 1 genes. Matrix, nonstructural protein, and polymerase basic 2 genes of some HPAI were most closely related to clade 2.1.3 instead of clade 2.3.2.1c, and a polymerase basic 2 gene was most closely related to Eurasian low pathogenicity avian influenza. Our results detected a total of 13 reassortment types among HPAI in Indonesia, mostly in backyard chickens in Indramayu.
Keywords
SDG 3 - Good Health and Well-being
Citation
Karo-Karo, D, Bodewes, R, Wibawa, H, Artika, M, Pribadi, E S, Diyantoro, D, Pratomo, W, Sugama, A, Hendrayani, N, Indasari, I, Wibowo, M H, Muljono, D H, Stegeman, J A & Koch, G 2019, 'Reassortments among Avian Influenza A(H5N1) Viruses Circulating in Indonesia, 2015-2016', Emerging Infectious Diseases, vol. 25, no. 3, pp. 465-472. https://doi.org/10.3201/eid2503.180167