Site-specific conjugation of single domain antibodies to liposomes enhances photosensitizer uptake and photodynamic therapy efficacy
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Publication date
2016-03-28
Authors
Broekgaarden, Mans
van Vught, R.W.M.
Oliveira, Sabrina
Roovers, Rob C.
van Bergen En Henegouwen, Paul Mp
Pieters, Roland J
Van Gulik, T. M.
Breukink, E.J.
Heger, Michal
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Document Type
Article
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taverne
Abstract
Photodynamic therapy for therapy-resistant cancers will greatly benefit from targeted delivery of tumor photosensitizing agents. In this study, a strategy for the site-specific conjugation of single domain antibodies onto liposomes containing the photosensitizer zinc phthalocyanine was developed and tested.
Keywords
Taverne, General Materials Science, SDG 3 - Good Health and Well-being
Citation
Broekgaarden, M, Van Vught, R, Oliveira, S, Roovers, R C, Van Bergen En Henegouwen, P M P, Pieters, R J, Van Gulik, T M, Breukink, E & Heger, M 2016, 'Site-specific conjugation of single domain antibodies to liposomes enhances photosensitizer uptake and photodynamic therapy efficacy', Nanoscale, vol. 8, no. 12, pp. 6490-6494. https://doi.org/10.1039/c6nr00014b