Position Paper: Rationale for the treatment of Wilms tumour in the UMBRELLA SIOP-RTSG 2016 protocol
Publication date
2017-12-01
Authors
van den Heuvel-Eibrink, Marry M
Hol, Janna A.
Pritchard-Jones, Kathy
van Tinteren, Harm
Furtwängler, Rhoikos
Verschuur, Arnauld C.
Vujanic, Gordan M.
Leuschner, Ivo
Brok, Jesper
Rübe, Christian
Editors
Advisors
Supervisors
Document Type
Article
Metadata
Show full item recordCollections
License
Abstract
The Renal Tumour Study Group of the International Society of Paediatric Oncology (SIOP-RTSG) has developed a new protocol for the diagnosis and treatment of childhood renal tumours, the UMBRELLA SIOP-RTSG 2016 (the UMBRELLA protocol), to continue international collaboration in the treatment of childhood renal tumours. This protocol will support integrated biomarker and imaging research, focussing on assessing the independent prognostic value of genomic changes within the tumour and the volume of the blastemal component that survives preoperative chemotherapy. Treatment guidelines for Wilms tumours in the UMBRELLA protocol include recommendations for localized, metastatic, and bilateral disease, for all age groups, and for relapsed disease. These recommendations have been established by a multidisciplinary panel of leading experts on renal tumours within the SIOP-RTSG. The UMBRELLA protocol should promote international collaboration and research and serve as the SIOP-RTSG best available treatment standard.
Keywords
Urology
Citation
Van Den Heuvel-Eibrink, M M, Hol, J A, Pritchard-Jones, K, van Tinteren, H, Furtwängler, R, Verschuur, A C, Vujanic, G M, Leuschner, I, Brok, J, Rübe, C, Smets, A M J B, Janssens, G O, Godzinski, J, Ramírez-Villar, G L, Camargo, B D, Segers, H, Collini, P, Gessler, M, Bergeron, C, Spreafico, F & Graf, N 2017, 'Position Paper : Rationale for the treatment of Wilms tumour in the UMBRELLA SIOP-RTSG 2016 protocol', Nature Reviews. Urology, vol. 14, no. 12, pp. 743-752. https://doi.org/10.1038/nrurol.2017.163